Cost-Effectiveness of Unrelated Hematopoietic Stem Cell Transplantation Versus Chemotherapy for Consolidation Treatment to Acute Myeloid Leukemia in High-Risk Pediatric Patients
Objetive: To assess the cost effectiveness of unrelated stem cell transplantation versus consolidation chemotherapy in pediatric population with high-risk acute myeloid leukemia (AML).Methods: A decision tree model was built with life years gained as outcome, from the perspective of the health system, including all direct costs. Pharmaceutical prices were obtained from the official System of Information of Medicaments SISMED (2008), and the value of procedures was calculated from the 2001 ISS tariff manual adding 30%. All monetary amounts are expressed in Colombian pesos of 2010. No discount rate was applied as costs are incurred during the first year. The cost-effectiveness threshold used was three times the 2010 per capita GDP per life year gained. Deterministic and probabilistic sensitivity analyses were performed over the variables with the higher effect on the incremental cost-effectiveness ratio (ICER).Results: The ICER of transplantation was $9.226.421, which is lower than the per capita GDP of 2010, $12.047.418. Results are robust to changes in the model data. Probabilistic sensitivity analysis with ten thousand simulations showed that unrelated transplant has a 70% probability of being cost effective.Conclusions: In the Colombian health system, unrelated stem cell transplantation is a cost-effective strategy for the treatment of high risk AML in pediatric patients
Year of publication: |
2013
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Authors: | García Molina, Mario |
Other Persons: | Chicaíza, Liliana (contributor) ; Quitian, Hoover (contributor) ; Linares Ballesteros, Adriana (contributor) ; Ramírez Wurttemberger, Óscar (contributor) |
Publisher: |
[2013]: [S.l.] : SSRN |
Subject: | Patienten | Patients | Gesundheitswesen | Health care system | Krankenhaus | Hospital | Arzneimittel | Pharmaceuticals |
Saved in:
freely available
Extent: | 1 Online-Ressource (33 p) |
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Series: | |
Type of publication: | Book / Working Paper |
Language: | English |
Notes: | Nach Informationen von SSRN wurde die ursprüngliche Fassung des Dokuments July 25, 2012 erstellt |
Other identifiers: | 10.2139/ssrn.2194560 [DOI] |
Classification: | D61 - Allocative Efficiency; Cost-Benefit Analysis ; I10 - Health. General ; I12 - Health Production: Nutrition, Mortality, Morbidity, Substance Abuse and Addiction, Disability, and Economic Behavior ; I19 - Health. Other |
Source: | ECONIS - Online Catalogue of the ZBW |
Persistent link: https://www.econbiz.de/10013089227