Effects of Micro or Nano Size on the Biocompatibility of Uio67 from Protein Adsorption Behavior, Hemocompatibility and Histological Toxicity
Metal–organic frameworks (MOFs), as a promising porous material applied in widespread fields, its biocompatibility is a necessary prerequisite to serve human life but is far from being addressed enough. Focus on the effects of size on the biocompatibility of MOFs, this study selected UiO67 with micron and nano size as the MOFs model (m-UiO67 and n-UiO67). Under the dose metric of surface area, the binding constant of the m-UiO67 was larger by about an order of magnitude than that of n-UiO67. Nano sized n-UiO67 induced stronger conformational transformation and impacted greater on the protein surface hydrophobicity compared with m-UiO67. m-UiO67 inhibited the esterase-like activity of HSA through competitive inhibition mechanism, while n-UiO67 inhibited that via non competitive inhibition mechanism. UiO67 in all sizes had well hemocompatibility, but n-UiO67 had better hemolysis and coagulation functions. Cytotoxicity test in vitro revealed that m-UiO67 showed better cellular activity than n-UiO67. For in vivo toxicity evaluations, both m- and n-UiO67 did not cause obvious distortion of organs, and they were mainly metabolized in the kidney. Results of this work may provide some useful information about the toxicity of MOFs to human health and experimental references for the development of MOFs-based engineered materials
Year of publication: |
[2022]
|
---|---|
Authors: | Gan, Na ; Peng, Xu ; Xiang, Hongzhao ; Sun, Qiaomei ; Yi, Bin ; Suo, Zili ; Zhang, Shuangshuang ; Wang, Xin-Long ; Li, Hui |
Publisher: |
[S.l.] : SSRN |
Saved in:
freely available
Saved in favorites
Similar items by person
-
Ji, Lingmei, (2022)
-
Chen, Jindao, (2021)
-
Internet Use and Fertility Behavior among Reproductive-Age Women in China
Nie, Peng, (2022)
- More ...