Azriel, David - In: Statistics & Probability Letters 82 (2012) 5, pp. 902-906
The continual reassessment method (CRM) is a model-based design that aims at finding the maximum tolerated dose (MTD) of a given drug. As the CRM is a model-based technique, its use may be restricted to cases where the true dose-response curve satisfies its underlying working model. Shen and...