Lai, Chin-Ying; Tian, Lili; Schisterman, Enrique F. - In: Computational Statistics & Data Analysis 56 (2012) 5, pp. 1103-1114
classifying a patient into the non-diseased or diseased group, an optimal cut-point of a continuous biomarker is desirable. Youden … measure of overall diagnostic accuracy and can be used in choosing an optimal cut-point. The proposed approach is to make use … of a generalized approach to estimate the confidence intervals of the Youden index and its corresponding optimal cut-point …