Bayesian optimal designs for binary longitudinal responses analyzed with mixed logistic regression describing a linear time effect are considered. In order to find the optimal number and allocations of time points, for different priors, cost constraints and covariance structures of the random...

Customarily, the choice between one- or two-colour microarray platforms is based on their respective practical and technical merits, contingent on objectives and constraints of the study at stake. Statistical efficiency, if accounted for, plays a secondary role. A cost-efficiency comparison of...

Optimal design problems for logistic mixed effects models for binary longitudinal responses are considered. A function of the approximate information matrix under the framework of the Penalized Quasi Likelihood (PQL) and a generalized linear mixed model with autocorrelation is optimized. Locally...

This paper reports a study of the relationship between the use of physical restraints with psycho-geriatric nursing home residents and the characteristics of organisations and residents. It is hypothesised that impairment in residents and organisational characteristics, such as a high workload...

In health sciences, medicine and social sciences linear mixed effects models are often used to analyse time-structured data. The search for optimal designs for these models is often hampered by two problems. The first problem is that these designs are only locally optimal. The second problem is...