Marta, Padilla; Bickel David R. - In: Statistical Applications in Genetics and Molecular Biology 11 (2012) 5, pp. 1-42
Histogram-based empirical Bayes methods developed for analyzing data for large numbers of genes, SNPs, or other biological features tend to have large biases when applied to data with a smaller number of features such as genes with expression measured conventionally, proteins, and metabolites....