Introduction: Immunosuppressive therapy is required to prevent graft rejection. Calcineurin inhibitors such as tacrolimus are paradoxically toxic to the kidney, whereas sirolimus (rapamycin; Rapamune(R)) is not generally associated with the nephrotoxicity of CNIs. The purpose of this study was...

Objective: To estimate the cost effectiveness of representatives of three different classes of antidepressants used in major depression in the UK NHS. Design, patients and interventions: A decision-tree model for the treatment of major depression was constructed by interviewing UK GPs and...