Children with complicated severe acute malnutrition (SAM) admitted to hospital in sub-Saharan Africa have a case fatality between 12% and more than 20%. Because children with SAM may not exhibit the usual signs of infection, WHO guidelines recommend routine antibiotics. However, this is based on...

The effectiveness of insecticide-treated materials had been unclear, as earlier studies had based their results on the effects on vectors rather than on human morbidity and mortality rates from malaria. In 1988 the UK Medical Research Council began a systematic trial of a combined intervention...