Jin, Ick Hoon; Liu, Suyu; Thall, Peter F.; Yuan, Ying - In: Journal of the American Statistical Association 109 (2014) 506, pp. 525-536
A practical impediment in adaptive clinical trials is that outcomes must be observed soon enough to apply decision rules to choose treatments for new patients. For example, if outcomes take up to six weeks to evaluate and the accrual rate is one patient per week, on average three new patients...