Asger, Hobolth; Ledet, Jensen Jens - In: Statistical Applications in Genetics and Molecular Biology 4 (2005) 1, pp. 1-22
We describe statistical inference in continuous time Markov processes of DNA sequences related by a phylogenetic tree. The maximum likelihood estimator can be found by the expectation maximization (EM) algorithm and an expression for the information matrix is also derived. We provide explicit...