We present a novel characterization of the generalized family wise error rate: kFWER. The interpretation allows researchers to view kFWER as a function of the test statistics rather than current methods based on p-values. Using this interpretation we present several theorems and methods...

In a multiple testing setting, the investigator is faced with choosing a method for controlling the Type I error rate. In this manuscript, we derive and compare the exact distribution for the number of false positives under a commonly used distribution. The results from this work can be extended...

Array Comparative Genomic Hybridization (aCGH) is an array-based technology which provides simultaneous spot assays of relative genetic abundance (RGA) levels at multiple sites across the genome. These spot assays are spatially correlated with respect to genomic location and, as a result, the...