The algorithm described here, called OptQuest/NLP or OQNLP, is a heuristic designed to find global optima for pure and mixed integer nonlinear problems with many constraints and variables, where all problem functions are differentiable with respect to the continuous variables. It uses OptQuest,...

Intravenous patient-controlled analgesia (PCA) can provide improved postoperative pain control compared with traditional methods, while maintaining safety. However, poorly managed PCA cannot be expected to provide good analgesia and may increase the risk of adverse events. Effective use of PCA...