American Recovery and Reinvestment Act of 2009 comparative effectiveness research (CER) investments aimed to develop fundamental building blocks to transform health care in the United States by strategically aligning national CER efforts and priorities. The overarching goals of these investments...

We conducted a midstream assessment of the $46 million investment in comparative effectiveness research (CER) training programs funded by the American Recovery and Reinvestment Act (ARRA). The 43 ARRA-supported CER training programs enhanced workforce capacity by developing curricula and...

Multidisciplinary, multi-institutional collaboration has become a key feature of comparative effectiveness research (CER), and CER funders have made promotion of these types of collaboration an implicit, and sometimes explicit, goal of funding. An important challenge in evaluating CER programs...

As part of the evaluation of the American Recovery and Reinvestment Act (ARRA) investment in comparative effectiveness research (CER), Mathematica developed a conceptual framework to guide future efforts to assess the impact of CER. In addition, we explored methodological challenges related to...

To improve health outcomes, clinicians and patients must have evidence-based information available to help them make informed decisions, the knowledge and skills to use this information, and positive attitudes about the value of using comparative effectiveness research (CER) in decision making....

This article discusses the implications of diagnostic errors for comparative effectiveness research (CER). It notes the potential role of CER studies for improving diagnosis and treatment decisions and the value of expanding the CER agenda to address misdiagnosis.

This article presents methodological and design issues for researchers to consider when addressing disability-related comparative effectiveness research questions.