Wu, Samuel S.; Wang, Weizhen; Yang, Mark C. K. - In: Biometrika 97 (2010) 2, pp. 405-418
In the first stage of a two-stage, drop-the-losers design, a candidate for the best treatment is selected. At the second stage, additional observations are collected to decide whether the candidate is actually better than the control. The design also allows the investigator to stop the trial for...