The pharmacokinetic (PK) analysis of breast MRI data using prior methods like the Tofts model-based approaches involved the estimation of the amount of contrast agent (CA) fed to the tissue, called the Arterial Input Function (AIF). The Mohan-Shinagawa model (hence-forth referred to as the M-S...

This study was conducted to develop a method, termed 'back analysis (BA)', for converting non-compartmental variables to compartment model dependent pharmacokinetic parameters for both one- and two-compartment models. A Microsoft Excel((R)) spreadsheet was implemented with the use of Solver((R))...

Background and Objectives:Background and Objectives: Economic value is an important consideration during all phases of the drug development process. We previously published an article in PharmacoEconomics in which we described a mechanism-based economic modelling approach that incorporates data...

Capillary whole blood point-of-care instruments for prothrombin time testing have been available for the last 10 years for use both in an office or hospital setting as well as at home by patients for self-monitoring of oral anticoagulant therapy. There are currently 4 types of instruments...