In the paper basic epidemiological indicators, produced by an aging population of vectors, are calculated. In the study we follow two lines: calculations for demographically structured population and individual life-history approach. We discuss the advantages and limitations of these approaches...

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In this paper, a recently developed mathematical model of age related changes in population of peripheral T cells (Romanyukha, Yashin, 2003) is used to describe ontogenetic changes of the immune system. The treatise is based on the assumption of linear dependence of antigen load from basal...

A mixture model in multivariate survival analysis is presented, whereby heterogeneity among subjects creates divergent paths for the individual's risk of experiencing an event (i.e., disease), as well as for the associated length of survival. Dependence among competing risks is included and...

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Individuals at the same age in the same population differ along numerous risk factors that affect their chances of various causes of death. The frail and susceptible tend to die first. This differential selection may partially account for some of the puzzles in cancer epidemiology, including the...

As one aspect of the complex feature of longevity, gene-sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing gene-sex interaction are expected. New and valid statistical methods are needed. In this paper, we...

Cause-specific mortality data on Danish monozygotic (MZ) and dizygotic (DZ) twins are used to analyze the influence of smoking and body mass index (BMI) on heritability estimates of susceptibility to coronary heart disease (CHD). The sample includes 1209 like-sexed twin pairs born between 1890...

Analysis of data on cancer incidence rates in different countries at different time periods revealed positive association between overall cancer risk and economic progress. Typical explanations of this phenomenon involve improved cancer diagnostics and elevated exposure to carcinogens in...