We analyze the financial performance of a hypothetical portfolio of 120 mRNA vaccine candidates in the preclinical stage targeting 11 emerging infectious diseases. We calibrate the simulation parameters with input from domain experts in mRNA technology and an extensive literature review. We find...

The portfolio approach of financing drug development has been proposed as a financial innovation to improve the risk/return tradeoff of investment in drug development projects through the use of diversification and securitization. By investing in a sizable and well-diversified portfolio of novel...

We study a prescriptive model for end-to-end design of a supply chain for medical countermeasures (MCM) to defend against bioattacks. We model the defender's MCM inventory prepositioning and dispensing capacity installation decisions, attacker's move, and defender's adjustable shipment...

When should a firm diversify its supply base? Most extant theories attribute supplier diversification to supplier risk. Herein, we develop a new theory that attributes supplier diversification to buyer risk. When suppliers are subject to the risk of buyer default, buyers may take costly action...

The paper shows that platform tokenization can alleviate underprovision of non-contractible entrepreneurial effort. We consider an entrepreneur who uses outside financing and exerts private effort to build a platform, and users who decide whether to join in response to the platform's dynamic...

We study a network revenue management model in which a decision maker offers multiple products, which consume capacitated resources, for sale to customers over a finite horizon. The decision maker employs an anonymous posted-price policy, and arriving customers strategize on (a) when, and (b)...

We study how to admit and schedule heterogeneous patients by using simple, interpretable, yet effective policies when capacity is scarce, no-show behavior is patient- and time-dependent, and overtime is costly. Our work is motivated by the aforementioned operational challenges that typically...