The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It is a key step to analyse the processes involved in the formation of DNA adducts which are connected with the development of chemical-induced cancer. A general problem...

A basic step in the risk assessment of potential carcinogens is the determination of toxicokinetic parameters. The present approach is part of a strategy to determine the processes of uptake, elimination, and metabolism of the gas ethylene, an important industrial chemical, which is classified...

In this paper we present a new method for estimating genetic parameters of an F2- generation model. Using an iterative algorithm we derive explicit expressions for the Maximum Likelihood estimates of the additive and dominance effects. Finally we calculate the variance covariance matrix of our...

Do active vertical mass movements occur within a population of phototropic bacteria in the meromictic Lake Cadagno. An experiment was conducted in vivo to record vertical profiles of the parameters turbidity and temperature in a spatial resolution of 30 cm repeatedly over time. After eliminating...

Research concerning the quantitative trait loci (QTL) mapping in plant genetics usually consists of two stages. The first stage is concerned with collecting data while the second one, based on the data collected, is concerned with a proper QTL study. The final inferences are strictly connected...

The properties of Cpmk in the presence of asymmetric specification limits are discussed. It is shown that Cpmk tends to zero as the process variation increases and vice versa. Furthermore, if the process variation is small, Cpmk has its maximum near the target value but the maximum moves towards...

In this paper, we examine the German business cycle (from 1955 to 1994) in order to identify univariate and multivariate outliers as well as influence points corresponding to Linear Discriminant Analysis. The locations of the corresponding observations are compared and economically interpreted.