We analyze the financial performance of a hypothetical portfolio of 120 mRNA vaccine candidates in the preclinical stage targeting 11 emerging infectious diseases. We calibrate the simulation parameters with input from domain experts in mRNA technology and an extensive literature review. We find...

The portfolio approach of financing drug development has been proposed as a financial innovation to improve the risk/return tradeoff of investment in drug development projects through the use of diversification and securitization. By investing in a sizable and well-diversified portfolio of novel...

On-demand ridesharing aims to fulfill riders' transportation needs whenever and wherever they want. Although this service level is appealing for riders, overall system efficiency can improve substantially if riders are willing to be flexible. Riders' flexibility in time has previously been...

How are scholars ranked for promotion, tenure and honors? How can we improve the quantitative tools available for decision makers when making such decisions? Can we predict the academic impact of scholars and papers at early stages using quantitative tools?Current academic decisions (hiring,...

Given a European derivative security with an arbitrary payoff function and a corresponding set ofquot; underlying securities on which the derivative security is based, we solve the dynamic replication problem: find aquot; self-financing dynamic portfolio strategy involving only the underlying...

A periodical multi-product pricing and inventory control problem with applications to production planning and airline revenue management is studied. The objective function of the single-period model is shown to be convex for certain types of demand distributions, thus tractable for large...

A fundamental problem faced by firms is that of product line design: given a set of candidate products that may be offered to a collection of customers, what subset of those products should be offered so as to maximize the profit that is realized when customers make purchases according to their...