We consider a dose-finding trial in phase IIB of drug development. For choosing an appropriate design for this trial the specification of two points is critical: an appropriate model for describing the dose-effect relationship and the specification of the aims of the trial (objectives), which...

We consider the problem of constructing optimal designs for model discrimination between competing regression models. Various new properties of optimal designs with respect to the popular T-optimality criterion are derived, which in many circumstances allow an explicit determination of T-optimal...

Classical regression analysis is usually performed in two steps. In a first step an appropriate model is identified to describe the data generating process and in a second step statistical inference is performed in the identified model. An intuitively appealing approach to the design of...

We consider the design problem for the estimation of several scalar measures suggested in the epidemiological literature for comparing the success rate in two samples. The designs considered so far in the literature are local in the sense that they depend on the unknown probabilities of success...

The current unemployment insurance and employment protection legislation were set up in an economic environment in which relationships between workers and firms were typically long-lasting and stable. The increasing globalisation of the economy and the rapid technological and organisational...

The current unemployment insurance and employment protection legislation were set up in an environment in which relationships between workers and firms were typically long-lasting and stable. The increasing globalisation of the economy and the rapid technological and organisational changes...

The general public considers Fixed-Route Transit (FRT) to be inconvenientwhile Demand-Responsive Transit (DRT) provides much of the desired flexibility with adoor-to-door type of service. However, FRT is typically more cost efficient than DRT todeploy. Therefore, there is an increased interest...

Estimation of flow volumes in computer networks involves the use of data that are either highly aggregated or fairly noisy. We address several conceptual and practical aspects of the use of such data for flow volume estimation in this work. The results presented are often of general statistical...

Doctor of Philosophy