Brannath, W.; Gutjahr, G.; Bauer, P. - In: Journal of the American Statistical Association 107 (2011) 498, pp. 824-832
Adaptive designs allow the investigator of a confirmatory trial to react to unforeseen developments by changing the design. This broad flexibility comes at the price of a complex statistical model where important components, such as the adaptation rule, remain unspecified. It has thus been...