Background and Objectives:Background and Objectives: Economic value is an important consideration during all phases of the drug development process. We previously published an article in PharmacoEconomics in which we described a mechanism-based economic modelling approach that incorporates data...

Bootstrapping is used to estimate the effectiveness of different vaccination strategies for rubella in England and Wales. It is assumed that rubella infection follows the deterministic age-structured model discussed by Dietz and Schenzle (1985). The bootstrap is used to estimate percentile...

Consider the linear regression model with uncorrelated errors and an experimental design ξ. In the article, we address the problem of calculating the minimal efficiency of ξ with respect to the class [InlineMediaObject not available: see fulltext.] of orthogonally invariant information...

In mixture experiments, optimal designs for the estimation of parameters, both linear and non-linear, have been discussed by several authors. In this paper, we attempt to find the optimum designs for testing the presence of synergistic effects in a mixture model using the maximin criterion.