Continuum and compartmental models are presented as alternative descriptions of the electrical behaviour of a dendrite. The one-dimensional continuum model provides a reference against which the accuracy of compartmental models may be assessed. Traditional compartmental models are shown to be...

Purpose: Observational studies may provide important information on the long-term effects of treatments for epilepsy, but systematic reviews of observational studies may be more prone to heterogeneity and biases. These issues were investigated in a systematic review of non-randomised add-on...

In this work we develop an approach to extracting information from neural spike trains. Using the expectation-maximization (EM) algorithm, interspike interval data from experiments and simulations are fitted by mixtures of distributions, including Gamma, inverse Gaussian, log-normal, and the...

We describe a quantitative and comparative review of a selection of European birthweight standards for gestational age for singletons, to enable appropriate choices to be made for clinical and research use. Differences between median values at term across standards in 10 regions and...

Evoked potentials are usually evaluated subjectively, by visual inspection, and considerable differences between interpretations can occur. Objective, automated methods are normally based on calculating one (or more) parameters from the data, but only some of these techniques can provide...

Decision trees are hierarchical, sequential classification structures that recursively partition the set of observations (data) and are used to represent rules underlying the observations. This article describes the development of TreeWorks, a tool that enhances existing decision tree theory and...

This paper describes the development and application of a simulation tool for modelling patient choice in healthcare systems. Patient choice is already offered in the English National Health Service (NHS) and proposed reforms will propel choice to the forefront of NHS re-structuring by offering...

Firms often delegate important decisions to committees which are set up specifically for that purpose; for example selection committees. We analyze the equilibrium behavior of a game in which committee members (the players) interview candidates sequentially, either hiring or going on to the next...

This paper studies the estimation of a semi-strong GARCH(1,1) model when it does not have a stationary solution, where semi-strong means that we do not require the errors to be independent over time. We establish necessary and sufficient conditions for a semi-strong GARCH(1,1) process to have a...

We propose estimators of previous termfeatures of the distributionnext term of an unobserved random variable W. What is observed is previous termanext term sample of Y,V,X where previous termanext term binary Y equals one when W exceeds previous termanext term threshold V determined by...