Statistical modeling and inference problems with sample sizes substantially smaller than the number of available covariates are challenging. This is known as large p small n problem. Furthermore, the problem is more complicated when we have multiple correlated responses. We develop multivariate...

A functional classification methodology, based on the Reproducing Kernel Hilbert Space (RKHS) theory, is proposed for discrimination of gene expression profiles. The parameter function involved in the definition of the functional logistic regression is univocally and consistently estimated, from...

In this paper, we develop a fast algorithm for a smoothing spline estimator in multivariate regression. To accomplish this, we employ general concepts associated with roughness penalty methods in conjunction with the theory of radial basis functions and reproducing kernel Hilbert spaces. It is...