This Test Guideline describes an in vitro screen for chemical effects on steroidogenesis, specifically the production of 17ß-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma cell line, used for the assay, expresses genes that encode for all the key enzymes for...

How can the environmental effects of trade liberalisation agreements be assessed ? Are available methodologies sufficiently tuned to current concerns? In order to take stock of the state of the art in assessment methodologies, the OECD organised a two-day technical workshop to focus on past...

City and regional governments as well as development agencies will learn from this report how to develop their own toolbox of instruments and structures for leveraging private finance. What role can private financing play in local economic development? To address this issue, this study draws on...

The purpose of the test is to measure the capacity of a chemical to activate or inhibit the transcription of a genetic construct (THb/ZIP-GFP X. laevis eleutheroembryos) either by binding to the thyroid hormone receptor or by modifying the amount of thyroid hormone available for transcription....