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A Statistical Method for Constructing Transcriptional Regulatory Networks Using Gene Expression and Sequence Data

Xing, Biao; Laan, Mark van der - Berkeley Electronic Press - 2004

Transcriptional regulation is one of the most important means of gene regulation. Uncovering transcriptional regulatory network helps us to understand the complex cellular process. In this paper, we describe a comprehensive statistical approach for constructing the transcriptional regulatory...

Persistent link: https://www.econbiz.de/10005459077

Multiple Testing and Data Adaptive Regression: An Application to HIV-1 Sequence Data

Birkner, Merrill; Sinisi, Sandra; Laan, Mark van der - Berkeley Electronic Press - 2004

Analysis of viral strand sequence data and viral replication capacity could potentially lead to biological insights regarding the replication ability of HIV-1. Determining specific target codons on the viral strand will facilitate the manufacturing of target specific antiretrovirals. Various...

Persistent link: https://www.econbiz.de/10005246353

Multiple Testing. Part I. Single-Step Procedures for Control of General Type I Error Rates

Dudoit, Sandrine; Laan, Mark van der; Pollard, Katherine - Berkeley Electronic Press - 2004

error rate. A general bootstrap algorithm is supplied to conveniently obtain consistent estimators of the null distribution … hypotheses (van der Laan et al., 2003b). The proposed bootstrap multiple testing procedures are evaluated by a simulation study …

Persistent link: https://www.econbiz.de/10005246355

Multiple Testing. Part II. Step-Down Procedures for Control of the Family-Wise Error Rate

Laan, Mark van der; Dudoit, Sandrine; Pollard, Katherine - Berkeley Electronic Press - 2004

. A general bootstrap algorithm is supplied to conveniently obtain consistent estimators of the null distribution. …

Persistent link: https://www.econbiz.de/10005178540

Nonparametric Confidence Intervals for the One- and Two-Sample Problems

Zhou, Xiao-Hua; Dinh, Phillip - Berkeley Electronic Press - 2004

bootstrap-t, the biased-corrected acceleration (BCa) bootstrap, and three new intervals based on transformation of the t …-statistic. Our study shows that our new transformation intervals and the bootstrap-t intervals give best coverage accuracy for a …

Persistent link: https://www.econbiz.de/10005751054

Resampling methods for estimating functions with U-statistic structure

Jiang, Wenyu; Kalbfleisch, Jack - Berkeley Electronic Press - 2004

approximations as well as an estimating function bootstrap (EFB) method based on resampling the estimated terms in the estimating …

Persistent link: https://www.econbiz.de/10005579275