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Evaluating Markers for Selecting a Patient's Treatment
Song, Xiao; Pepe, Margaret - Berkeley Electronic Press - 2004
Selecting the best treatment for a patient's disease may be facilitated by evaluating clinical characteristics or biomarker measurements at diagnosis. We consider how to evaluate the potential of such measurements to impact on treatment selection algorithms. For example, magnetic resonance...
Persistent link: https://www.econbiz.de/10005751053
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Loss-Based Estimation with Cross-Validation: Applications to Microarray Data Analysis and Motif Finding
Dudoit, Sandrine; Laan, Mark van der; Keles, Sunduz; … - Berkeley Electronic Press - 2004
Current statistical inference problems in genomic data analysis involve parameter estimation for high-dimensional multivariate distributions, with typically unknown and intricate correlation patterns among variables. Addressing these inference questions satisfactorily requires: (i) an intensive...
Persistent link: https://www.econbiz.de/10005459073
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Combining Predictors for Classification Using the Area Under the ROC Curve
Pepe, Margaret; Cai, Tianxi; Zhang, Zheng - Berkeley Electronic Press - 2004
used for the two state classification task. Theoritical advantages of the robust procedure over logistic regression are: (i … function over the whole predictor space to achieve adequate classification properties. Procedures that restrict modeling to a … region provides a robust objective function for determining classification rules.Overall, our new procedure performs well but …
Persistent link: https://www.econbiz.de/10005246090