A simple, two period framework is used to interpret existing contributions to the literature on decision rules for HTA under uncertainty and to contrast them with a dynamic, economic model solved using backward induction.

In this paper we present an application for a multiobjective optimization problem. The objective functions of the primal problem are the risk and the expected pain associated to a portfolio vector. Then, we present a Lagrangian dual problem for it. In order to formulate this problem, we...

This paper compares dierent centralized collective models for maximizing the utility of a household from the point of view of the single members that compose it. We describe the collective maximization program as a vector optimization problem and analyze the household welfare and Pareto...

The paper uses a real option approach to investigate the potential impact of performance-based risk-sharing agreements for the reimbursement of new drugs in comparison with standard cost-effectiveness thresholds. The results show that the exact definition of the risk-sharing agreement is key in...

In this working paper we study some properties of a particular mapping in Rn related to an optimization problem with one equality constraint. We motivate the definition of the relevant mapping starting from a portfolio selection problem, in which we minimize the risk of an investment (the...

This study develops a household enterprise model extended to encompass recent advances in collective theory. We use a simulation model, in which production and consumption-leisure choices are represented along with the rule governing intra-household resource allocation, to analyze the income and...

In this working paper we go on with the study of a mapping in Rn associated to a quadratic optimization problem with one equality linear constraint. After showing some general properties related to homogeneity and the inverse mapping, we present some results regarding how the mapping behaves...

This paper aims at studying, in the image space, an approximation of a vector optimization problem obtained by substituting the involved functions with their G-derivatives. It is shown that, under the hypothesis of G-differentiability, the existence of a semistationary point is equivalent to the...

The paper proposes a methodology to measure the characteristics of intermediate products when quality is multidimensional. It uses a general representation of the multioutput technology via directional distance functions and constructs quality indicators based on differences. The quality...

In this paper we investigate the valuation and optimal timing of the launch of two complementary/substitute products (or projects), one of which is a pilot product. As a first step, we study the problem from a strategic point of view and analyze the ability of the pilot product per se to create...