This Test Guideline is used in the assessment and evaluation of the toxic effects of organophosporus substances. Daily … doses of the test substance are administered orally (preferably by gavage or administration of gelatin capsules) to domestic … with the aim of inducing toxic effects; thereafter a descending sequence of dose levels should be selected. A limit test …

This Test Guideline describes an in vitro screen for chemical effects on steroidogenesis, specifically the production …, cells are exposed for 48 h to seven concentrations of the test chemical in at least triplicate. Solvent and a known …

This test measures chromosome events in spermatogonial germ cells and is, therefore, expected to be predictive of … test substance (liquid or solid) by an appropriate route of exposure, usually by gavage or by intraperitoneal injection … analysable males. Test substances are preferably administered once or twice but they may also be administered as a split dose to …

Following the OECD Council decision, the Test Guideline 480 ‘Genetic Toxicology: Saccharomyces cerevisiae, Gene …

The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and … test is that it detects mutations which revert mutations present in the test strains and restore the functional capability … of the bacteria to synthesize an essential amino acid. Suspensions of bacterial cells are exposed to the test substance …

test substance (liquid, solid, vapour or gas, …) indicates that the substance has affected germinal tissue of the test … anomalies), but gene mutations and toxic effects cannot be excluded. This Test Guideline recommends rats or mice as the test … species. Generally, male animals are exposed to the test substance and mated to untreated virgin females. The most widely used …

This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial … purpose of the in vivo mammalian spermatogonial chromosomal aberration test is to identify those chemicals that cause … structural chromosomal aberrations in mammalian spermatogonial cells (1) (2) (3). In addition, this test is relevant to assessing …

This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial … purpose of the in vivo mammalian spermatogonial chromosomal aberration test is to identify those chemicals that cause … structural chromosomal aberrations in mammalian spermatogonial cells (1) (2) (3). In addition, this test is relevant to assessing …