On 22 March 2000 the CCP held a half-day Forum Session intended to explore the challenges and possibilities associated with international co-operation. Using the experience of the United States and Canada as a practical example, the session provided an overview of ongoing efforts to combat the...

This Test Guideline has been designed to obtain the information necessary to confirm or to further characterise the potential neurotoxicity of chemicals in adult animals. This Test Guideline is designed for use with the rat. It specifically addresses the daily oral administration, by gavage, (in...

This Test Guideline describes a method to determine experimentally Pow values in the range log Pow between -2 and 4 (occasionally up to 5). This method can not be used with surface-active materials. The partition coefficient is defined as the ratio of the equilibrium concentrations of a...

This Test Guideline includes two methods: a paper contact toxicity test and an artificial soil test. The recommended specie is Eisenia foetida (Michaelsen). The initial screening test (filter paper contact test) involves exposing earthworms to test substances on moist filter paper in order to...

This Test Guideline describes the HPLC method, which permits to determine the partition coefficient (n-octanol/water) (Pow).Reverse phase HPLC is performed on analytical columns packed with a solid phase containing long hydrocarbon chains chemically bound onto silica. The chemicals are retained...