The widely used proportional odds model is developed for correlated repeated ordinal score data, using a modified version of the generalized estimating equation (GEE) method for model fitting for a range of working correlation models. The algorithm developed estimates the correlation parameter,...

Adaptive seamless phase II/III clinical trial designs allowing treatment selection at an interim analysis have gained much attention because of their potential benefits compared to more conventional drug development programmes with separate trials for individual phases. A scenario of particular...