Additive models of the type y=f_1(x_1)+...+f_p(x_p)+e where f_j,j=1,...,p, have unspecified functional form, are flexible statistical regression models which can be used to characterize nonlinear regression effects. The basic tools used for fitting the additive model are the expansion in...

Various supervised learning and gene selection methods have been used for cancer diagnosis. Most of these methods do not consider interactions between genes, although this might be interesting biologically and improve classification accuracy. Here we introduce a new CART-based method to discover...

A shrinkage type estimator is introduced which has favorable properties in binary regression. Although binary observations are never very far away from the underlying probability, in all interesting cases there is a non-zero distance between observation and underlying mean. The proposed response...

Principal components are a well established tool in dimension reduction. The extension to principal curves allows for general smooth curves which pass through the middle of a p-dimensional data cloud. In this paper local principal curves are introduced, which are based on the localization of...

The main problem with localized discriminant techniques is the curse of dimensionality, which seems to restrict their use to the case of few variables. This restriction does not hold if localization is combined with a reduction of dimension. In particular it is shown that localization yields...

Common approaches to monotonic regression focus on the case of a unidimensional covariate and continuous dependent variable. Here a general approach is proposed that allows for additive and multiplicative structures where one or more variables have monotone influence on the dependent variable....

We describe a stochastic model based on a branching process for analyzing surveillance data of infectious diseases that allows to make forecasts of the future development of the epidemic. The model is based on a Poisson branching process with immigration with additional adjustment for possible...

Functional data analysis can be challenging when the functional objects are sampled only very sparsely and unevenly. Most approaches rely on smoothing to recover the underlying functional object from the data which can be difficult if the data is irregularly distributed. In this paper we present...