Cardiovascular disease is the leading cause of death in developed countries. It is estimated that about 15 million people worldwide die every year from heart disease, with a substantial proportion of these deaths occurring in developing nations. Congestive heart failure (CHF) is a condition that...

Despite a wealth of national treatment guidelines, algorithms, and clinical literature detailing the successful treatment of patients with depressive disorders, there remains a large gap between what is known to be ideal treatment of depression and the reality of current practice. Depression in...

Medication compliance is a classic problem for patients and healthcare providers and little progress has been made in improving it. The objective of this review is to enhance the understanding of medication compliance by means of a complex systems approach. The complex system approach includes...

Asthma in the US is widespread, with incidence rates and morbidity increasing dramatically over the last 2 decades. The cost of asthma-related morbidity and mortality is large. There is substantial and convincing evidence that environmental factors are associated with asthma exacerbation, and...

Objective: Patients with severe asthma often require short courses of oral corticosteroids in addition to their daily inhaled steroid to maintain adequate lung function. The objective of this study was to compare two management strategies for the treatment of severe asthma. A budesonide-based...

Most breast and ovarian cancers occur sporadically, but an estimated 5 to 10% of cases occur in women with hereditary predisposition to these cancers. Two genes, BRCA1 and BRCA2, have been identified, which, when altered, are thought to be responsible for most cases of hereditary breast and...

Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality and is associated with the consumption of considerable health resources worldwide. Initial treatment of patients with CAP is often empirical. Growing concern about the increasing prevalence of atypical organisms is...

The rapid expansion of disease management continues. A multitude of stakeholders and marketplaces are now involved in providing cost-effective quality healthcare for individuals and populations. To help you keep up-to-date with the very latest developments in disease management, this section of...

Pulmonary rehabilitation programs aim to improve the health of elderly patients disabled by lung disease. Despite the widespread application of these programs limited scientific data is available on the subject, except in chronic obstructive pulmonary disease (COPD). This review presents an...