Hypertension and diabetes mellitus are significant and independent risk factors for cardiovascular disease. Antihypertensive therapy reduces cerebrovascular and cardiovascular morbidity and mortality in patients with hypertension. Tight blood pressure (BP) control [target diastolic BP (DBP)...

The increasing speed at which new knowledge is generated and disseminated means that we have to learn knew ways of handling this information. Instead of trying to remember information in case we need it at a later date, we need to develop the skills of finding, appraising and using information...

There is now conclusive evidence to support the widely prescribed application of disease management programs in heart failure care. These strategies result in significant improvement in many barometers of care, including admission rates, prescription of disease modifying therapy, and improved...

The absence of government regulation in the US has left pharmaceutical companies free to set their own prices based on a number of market considerations. Historically, these have included not only ingredient, research and development costs, but also advertising, the drug's marginal...

The poor efficacy and tolerability of conventional antipsychotic treatment in schizophrenia, together with discovery of the

Pay-for-performance schemes share the common approach of offering financial incentives to healthcare providers for achieving specified performance targets. Such schemes are becoming increasingly popular with healthcare policy makers and funders worldwide, despite a relative lack of evidence on...