Maintaining a rich research and development (R&D) pipeline is the key to remaining competitive in many industrial sectors. Due to its nature, R&D activities are subject to multiple sources of uncertainty, the modeling of which is compounded by the ability of the decision maker to alter the...

We discuss methods for the solution of a multi-stage stochastic programming formulation for the resource-constrained scheduling of clinical trials in the pharmaceutical research and development pipeline. First, we present a number of theoretical properties to reduce the size and improve the...