CAR T-cell immunotherapy is a new development in the treatment of leukemia, promising a new era in oncology. Although so far, this procedure only helps 50-90% of patients and, like other cancer treatments, has serious side effects. In this work, we have proposed a controlled model for leukemia...

This paper focuses on the design and analysis of short-term control intervention measures seeking to suppress local populations of Aedes aegypti mosquitoes, the major transmitters of dengue and other vector-borne infections. Besides traditional measures involving the spraying of larvicides...

An elementary approach to a class of optimal control problems with pathwise state constraint is proposed. Based on spike variations of control, it yields simple proofs and constructive necessary conditions, including some new characterizations of optimal control. Two examples are discussed.

This paper studies fishery strategies in lakes, seas, and shallow rivers subject to agricultural and industrial pollution. The flowing pollutants are modeled by a nonlinear differential equation in a general manner. The logistic growth model for the fish population is modified to cover the...

In this paper we put forward a simple game-theoretical model of pollution control, where each country is in control of its own pollution, while the environmental effects of policies do not stop at country borders. In our noncooperative differential game, countries as players minimize the present...

We derive sufficient and necessary optimality conditions in terms of a stochastic maximum principle (SMP) for controls associated with cost functionals of mean-field type, under dynamics driven by a class of Markov chains of mean-field type which are pure jump processes obtained as solutions of...

Different strains of influenza viruses spread in human populations during every epidemic season. As the size of an infected population increases, the virus can mutate itself and grow in strength. The traditional epidemic SIR model does not capture virus mutations and, hence, the model is not...

This paper studies fishery strategies in lakes, seas, and shallow rivers subject to agricultural and industrial pollution. The flowing pollutants are modeled by a nonlinear differential equation in a general manner. The logistic growth model for the fish population is modified to cover the...

CAR T-cell immunotherapy is a new development in the treatment of leukemia, promising a new era in oncology. Although so far, this procedure only helps 50-90% of patients and, like other cancer treatments, has serious side effects. In this work, we have proposed a controlled model for leukemia...

This paper focuses on the design and analysis of short-term control intervention measures seeking to suppress local populations of Aedes aegypti mosquitoes, the major transmitters of dengue and other vector-borne infections. Besides traditional measures involving the spraying of larvicides...