HIV dynamic models, a set of ordinary differential equations (ODEs), have provided new understanding of the pathogenesis of HIV infection and the treatment effects of antiviral therapies. However, to estimate parameters for ODEs is very challenging due to the complexity of this nonlinear system....

The two-parameter Birnbaum--Saunders distribution is widely applicable to model failure times of fatiguing materials. Its maximum-likelihood estimators (MLEs) are very sensitive to outliers and also have no closed-form expressions. This motivates us to develop some alternative estimators. In...