A brief review is given of procedures for the collective analysis of a large number of significance tests. A simple procedure previously supplied for isolating 'real' effects on the basis of a large number of significance tests is generalized to deal with two-sided tests and is also related more...

Robust estimation of parameters, and identification of specific data points that are discordant with an assumed model, are often treated as different statistical problems. The two aims are, however, closely inter-related and in many cases the two analyses are required simultaneously. We present...

Case-control studies of genetic polymorphisms and gene-environment interactions are reporting large numbers of statistically significant associations, many of which are likely to be spurious. This problem reflects the low prior probability that any one null hypothesis is false, and the large...

Repeated neuropsychological measurements, such as mini-mental state examination (MMSE) scores, are frequently used in Alzheimer's disease (AD) research to study change in cognitive function of AD patients. A question of interest among dementia researchers is whether some AD patients exhibit...

Simultaneously testing a family of n null hypotheses can arise in many applications. A common problem in multiple hypothesis testing is to control Type-I error. The probability of at least one false rejection referred to as the familywise error rate (FWER) is one of the earliest error rate...

This paper is an overview of a unified framework for analyzing designed experiments with univariate or multivariate responses. Both categorical and continuous design variables are considered. To handle unbalanced data, we introduce the so-called Type II* sums of squares. This means that the...