Modelling of HIV dynamics in AIDS research has greatly improved our understanding of the pathogenesis of HIV-1 infection and guided for the treatment of AIDS patients and evaluation of antiretroviral therapies. Some of the model parameters may have practical meanings with prior knowledge...

Gene copy number (GCN) changes are common characteristics of many genetic diseases. Comparative genomic hybridization (CGH) is a new technology widely used today to screen the GCN changes in mutant cells with high resolution genome-wide. Statistical methods for analyzing such CGH data have been...

The mixed random effect model is commonly used in longitudinal data analysis within either frequentist or Bayesian framework. Here we consider a case, in which we have prior knowledge on partial parameters, while no such information on the rest of the parameters. Thus, we use the hybrid approach...

Ranked set sampling is a cost efficient sampling technique when actually measuring sampling units is difficult but ranking them is relatively easy. For a family of symmetric location-scale distributions with known location parameter, we consider a best linear unbiased estimator for the scale...

In this article, a simple algorithm is used to maximize a family of optimal statistics for hypothesis testing with a nuisance parameter not defined under the null hypothesis. This arises from genetic linkage and association studies and other hypothesis testing problems. The maximum of optimal...