Hu, Jiaqiao; Zhu, Wei; Su, Yi; Wong, Weng Kee - In: Journal of Statistical Software 35 (2010) i06
The assessment of dose-response is an integral component of the drug development process. Parallel dose-response studies are conducted, customarily, in preclinical and phase 1, 2 clinical trials for this purpose. Practical constraints on dose range, dose levels and dose proportions are intrinsic...