In longitudinal studies, we are often interested in modelling repeated assessments of volume over time. Our motivating example is an acupuncture clinical trial in which we compare the effects of active acupuncture, sham acupuncture and standard medical care on chemotherapy-induced nausea in...

type="main" xml:id="rssc12050-abs-0001" <title type="main">Summary</title> <p>A major issue in non-inferiority trials is the controversial assumption of constancy, namely that the active control has the same effect relative to placebo as in previous studies comparing the active control with placebo. The constancy assumption...</p>