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Continuous Time Simulation and Discretized Models for Cost-Effectiveness Analysis

Soares, Marta O.; Canto e Castro, Lusa - In: PharmacoEconomics 30 (2012) 12, pp. 1101-1117

The design of decision-analytic models for cost-effectiveness analysis has been the subject of discussion. The current work addresses this issue by noting that, when time is to be explicitly modelled, we need to represent phenomena occurring in continuous time. Models evaluated in continuous...

Persistent link: https://www.econbiz.de/10011005076

Methods of Model Calibration: Observations from a Mathematical Model of Cervical Cancer

Taylor, Douglas C.A.; Pawar, Vivek; Kruzikas, Denise; … - In: PharmacoEconomics 28 (2010) 11, pp. 995-1000

Background: Mathematical models are commonly used to predict future benefits of new therapies or interventions in the healthcare setting. The reliability of model results is greatly dependent on accuracy of model inputs but on occasion, data sources may not provide all the required inputs....

Persistent link: https://www.econbiz.de/10008677589

Population- versus Cohort-Based Modelling Approaches

Ethgen, Olivier; Standaert, Baudouin - In: PharmacoEconomics 30 (2012) 3, pp. 171-181

While no single type of model can provide adequate answers under all circumstances, any modelling endeavour should … are essentially two different approaches in modelling a population over time: a cohort-based approach and a population …

Persistent link: https://www.econbiz.de/10009493378

Selecting a Mix of Prevention Strategies against Cervical Cancer for Maximum Efficiency with an Optimization Program

Demarteau, Nadia; Breuer, Thomas; Standaert, Baudouin - In: PharmacoEconomics 30 (2012) 4, pp. 337-353

Background:Background: Screening and vaccination against human papillomavirus (HPV) can protect against cervical cancer. Neither alone can provide 100% protection. Consequently it raises the important question about the most efficient combination of screening at specified time intervals and...

Persistent link: https://www.econbiz.de/10009653279

A Critical Review of Model-Based Economic Studies of Depression: Modelling Techniques, Model Structure and Data Sources

Haji Ali Afzali, Hossein; Karnon, Jonathan; Gray, Jodi - In: PharmacoEconomics 30 (2012) 6, pp. 461-482

acute episodes/relapses. Although modelling techniques play an increasingly important role in the economic evaluation of … depression interventions, comparatively little attention has been paid to issues around modelling studies with a focus on … potential biases. This, however, is important as different modelling approaches, variations in model structure and input …

Persistent link: https://www.econbiz.de/10010548284

Economic Evaluation of Smoking-Cessation Therapies: A Critical and Systematic Review of Simulation Models

Bolin, Kristian - In: PharmacoEconomics 30 (2012) 7, pp. 551-564

mathematical modelling (both deterministic and stochastic) of future events important for cost effectiveness. Abstract: Objectives …:Objectives: This study surveys cost-effectiveness analyses of smoking cessation, with a particular focus on the mathematical modelling … modelling. Abstract: Conclusions:Conclusions: In general, studies are well performed as regards modelling. Common weaknesses …

Persistent link: https://www.econbiz.de/10010551729

New Clinical Insights into Chronic Obstructive Pulmonary Disease and Their Implications for Pharmacoeconomic Analyses

Mapel, Douglas W.; Roberts, Melissa H. - In: PharmacoEconomics 30 (2012) 10, pp. 869-885

such as Markov modelling, and they have usually found that newer therapies have favourable cost effectiveness. However, new …, known as exacerbations, and approaches to modelling the cost benefit of exacerbation reduction; (iii) quality …; (v) the limitations of Markov modelling; and (vi) the problem of outliers. …

Persistent link: https://www.econbiz.de/10010569819

Calibrating Models in Economic Evaluation: A Seven-Step Approach

Vanni, Tazio; Karnon, Jonathan; Madan, Jason; White, … - In: PharmacoEconomics 29 (2011) 1, pp. 35-49

In economic evaluation, mathematical models have a central role as a way of integrating all the relevant information about a disease and health interventions, in order to estimate costs and consequences over an extended time horizon. Models are based on scientific knowledge of disease (which is...

Persistent link: https://www.econbiz.de/10010614295

Decision-Analytic Models to Simulate Health Outcomes and Costs in Heart Failure: A Systematic Review

Goehler, Alexander; Geisler, Benjamin P.; Manne, Jennifer M. - In: PharmacoEconomics 29 (2011) 9, pp. 753-769

developed countries. Various decision-analytic modelling approaches exist to estimate the cost effectiveness of health … clinical trial or that were purely descriptive studies were excluded. We identified 34 modelling studies investigating …-aged to elderly patients with stable but progressed heart failure with systolic left ventricular dysfunction. Modelling …

Persistent link: https://www.econbiz.de/10010614299

Modelling the Epidemiology of Infectious Diseases for Decision Analysis: A Primer

Jit, Mark; Brisson, Marc - In: PharmacoEconomics 29 (2011) 5, pp. 371-386

The number of economic evaluations related to infectious disease topics has increased over the last 2 decades. However, many such evaluations rely on models that do not take into account unique features of infectious diseases that can affect the estimated value of interventions against them....

Persistent link: https://www.econbiz.de/10010614315