Several mathematical models have been proposed to predict the activation state of a transcription factor (TF) from the expression levels of its target genes. This inference problem is complicated however due to the fact that different genes may be regulated by different activation schemes...

The exact meaning of the noise spectrum of eigenvalues of the correlation matrix is discussed. In order to better understand the possible phenomena behind the observed noise, the spectrum of eigenvalues of the correlation matrix is studied under a model where most of the true eigenvalues are...