The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It’s a first step to analyse the processes which are involved in the development of DNA adducts and might therefore lead to the development of cancer. The complete...

Necessary and sufficient conditions for the equality of ordinary least squares and generalized least squares estimators in the linear regression model with firstorder spatial error processes are given.

In this paper we derive asymptotic x2-tests for general linear hypotheses on variance components using repeated variance components models. In two examples, the two-way nested classification model and the two-way crossed classification model with interaction, we explicitly investigate the...