As will be shown the current use of Desirability Indices for optimisation purposes in experimental design gives biased results in general. Researchers were satisfied with approximative solutions as unbiased results would have required analytical expressions for the distributions of Desirability...

The basic ideas of Desirability functions and indices are introduced and compared to other methods of multivariate optimisation. It is shown that gradient based techniques are not in general appropriate to perform the numerical optimisation for Desirability indices. The problems are shown for...