SRSA Fellows Address: Andy Isserman sums up his life's work and gives advice to young regional scientists, just months before his untimely passing. With a few memorial remarks by Sarah A. Low.

Regional science is turning 40. Once the harbinger of a person's imminent death, becoming 40 now ushers in a period of apprehension and reflection-the mid-life crisis. It is a time to confront the dreams of youth, take stock of the present, ponder the path that led from there to here, and...