An important problem in epidemiology and medical research is the estimation of a causal effect of a treatment action at a single point in time on the mean of an outcome within a population defined by strata of some of the observed covariates. Marginal structural models (MSM) are models for...

Cawley et al. (2004) have recently mapped the locations of binding sites for three transcription factors along human chromosomes 21 and 22 using ChIP-Chip experiments. ChIP-Chip experiments are a new approach to the genome-wide identification of transcription factor binding sites and consist of...

Multiple transcription factors coordinately control transcriptional regulation of genes in eukaryotes. Although multiple computational methods consider the identification of individual transcription factor binding sites (TFBSs), very few focus on the interactions between these sites. We consider...

Providing information about the risk of disease and clinical factors that may increase or decrease a patient's risk of disease is standard medical practice. Although case-control studies provide evidence of strong associations between diseases and risk factors, clinicians need to be able to...