Economic globalization has put pressure on companies to strive for cost reductions, increases in quality and shorter production cycles. Similar economic and technological trends have stimulated and determined the emergence of new management paradigms. Business process integration (BPI) is...

The dissertation presents GALAS models for the estimation of the acute toxicity towards two rodent species following different administration routes as well as for the prediction of CYP3A4 and CYP2D6 regioselectivity in the main metabolic reactions mediated by these enzymes (13 individual models...