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The theory of autocatalytic binary ligation is reviewed within the context of a rigorously applied Michaelis-Menten quasi-steady-state approximation to obtain explicit analytical results describing time-course data from experiments. A detailed protocol for the step-wise elucidation of a minimal...
Persistent link: https://www.econbiz.de/10005837730
We demonstrate the existence of a phase transition in combinatorial optimization problems. For many of these problems, as local search algorithms are parallelized, the quality of solutions first improves and then sharply degrades to no better than random search. This transition can be...
Persistent link: https://www.econbiz.de/10005739966
Persistent link: https://www.econbiz.de/10004047711
A new approach to drug discovery is based on the generation of high diversity libraries of DNA, RNA, peptides or small molecules. Search of such libraries for useful molecules is an optimization problem of high-dimensional molecular fitness landscapes. We utilize a spin-glass-like model, the NK...
Persistent link: https://www.econbiz.de/10005790778
The most general aim of "Investigations" is to explore whether there might, conceivably, be some general laws governing a certain class of non-equilibrium systems - namely the class of coevolutionary self-constructing communities of autonomous agents. The first lecture discusses the general...
Persistent link: https://www.econbiz.de/10005790783
The Utilization of high diversity molecular libraries for dtug discovery in now becoming a cnetrally important and developing set of technologies, (Balliver and Kauffman 1986, 1989,1990, Geysen et. al 1987). Om he pase decade, efforts focused on two approaches: The first is ``genetic'' and based...
Persistent link: https://www.econbiz.de/10005790913
We argue that in classical and quantum theories of gravity the configuration space and Hilbert space may not be constructible through any finite procedure. If this is the case, then the ``problem of time'' in quantum cosmology may be a pseudo-problem, because the argument that time disappears...
Persistent link: https://www.econbiz.de/10005791021
Persistent link: https://www.econbiz.de/10006836788
In this study, we explore the relationships among group size, the extent of interactions with other groups, and group performance in a stochastic environment. We have developed a modeling framework which allows the connections among the individual members constituting a group and the connections...
Persistent link: https://www.econbiz.de/10005837691
Adaptive walks are an optimization technique for searching a space of possible solutions, for example, a space of different molecules. The goal is to find a point in space (a molecule) optimal or near-optimal in some property, generally referred to as the ``fitness,'' such as its ability to bind...
Persistent link: https://www.econbiz.de/10005837731