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Empirical Likelihood Confidence Intervals for the Sensitivity of a Continuous-Scale Diagnostic Test

Davis, Angela Elaine - 2007

lead to improved treatment and thus reduce medical mistakes. The sensitivity and specificity are two important measurements … confidence interval for the sensitivity at a fixed level of specificity for the test. In this thesis, we propose three empirical … likelihood intervals for the sensitivity. Simulation studies are conducted to compare the empirical likelihood based confidence …

Persistent link: https://www.econbiz.de/10009463421

Statistical Inferences for the Youden Index

Zhou, Haochuan - 2011

of sensitivity and specificity for all the possible values of the cut-point. This dissertation concentrates on …

Persistent link: https://www.econbiz.de/10009480799

Maximizing proportions of correct classifications in binary logistic regression

Hadjicostas, Petros - In: Journal of Applied Statistics 33 (2006) 6, pp. 629-640

addition, we give results that allow us to get all cut-off points that maximize a weighted combination of specificity and … sensitivity. In addition, we discuss measures of association between predicted probabilities and observed responses, and, in …

Persistent link: https://www.econbiz.de/10005458138

Accuracy of MSI Testing in Predicting Germline Mutations of MSH2 and MLH1: A Case Study in Bayesian Meta-Analysis of Diagnostic Tests Without a Gold Standard

Chen, Sining; Watson, Patrice; Parmigiani, Giovanni - Berkeley Electronic Press - 2004

sensitivity and specificity of MSI for detecting germline mutations of mismatch repair genes is critical in genetic counseling and …Microsatellite instability (MSI) testing is a common screening procedure used to identify families that may harbor … article we perform a meta-analysis of these studies and obtain estimates that can be directly used in counseling and screening …

Persistent link: https://www.econbiz.de/10005459211

Joint inference about sensitivity and specificity at the optimal cut-off point associated with Youden index

Yin, Jingjing; Tian, Lili - In: Computational Statistics & Data Analysis 77 (2014) C, pp. 1-13

In diagnostic studies, both sensitivity and specificity depend on cut-off point and they are well-known measures for …-off point associated with Youden index depends on both diseased and healthy samples, henceforth, sensitivity and specificity at … confidence region of sensitivity and specificity at the cut-off point determined by the Youden index. A real data set is analyzed …

Persistent link: https://www.econbiz.de/10010871381

Classification loss function for parameter ensembles in Bayesian hierarchical models

Ginestet, Cedric E.; Best, Nicky G.; Richardson, Sylvia - In: Statistics & Probability Letters 82 (2012) 4, pp. 859-863

, we also relate these classification loss functions on parameter ensembles to the concepts of posterior sensitivity and … specificity. Finally, we discuss the potential applications of balanced and p-weighted TCLs in Bayesian hierarchical models, and …

Persistent link: https://www.econbiz.de/10011040088

High-throughput DNA methylation datasets for evaluating false discovery rate methodologies

Asomaning, N.; Archer, K.J. - In: Computational Statistics & Data Analysis 56 (2012) 6, pp. 1748-1756

reporting the sensitivity, specificity, and observed FDR. These datasets are useful for characterizing the performance of …

Persistent link: https://www.econbiz.de/10010577727

Assessing mean and median filters in multiple testing for large-scale imaging data

Zhang, Chunming - In: TEST: An Official Journal of the Spanish Society of … 23 (2014) 1, pp. 51-71

A new multiple testing procedure, called the FDR<Subscript> L </Subscript> procedure, was proposed by Zhang et al. (Ann Stat 39:613–642, <CitationRef CitationID="CR12">2011</CitationRef>) for detecting the presence of spatial signals for large-scale 2D and 3D imaging data. In contrast to the conventional multiple testing procedure, the FDR<Subscript> L </Subscript> procedure...</subscript></citationref></subscript>

Persistent link: https://www.econbiz.de/10010994312

The linear combinations of biomarkers which maximize the partial area under the ROC curves

Hsu, Man-Jen; Hsueh, Huey-Miin - In: Computational Statistics 28 (2013) 2, pp. 647-666

As biotechnology has made remarkable progress nowadays, there has also been a great improvement on data collection with lower cost and higher quality outcomes. More often than not investigators can obtain the measurements of many disease-related features simultaneously. When multiple potential...

Persistent link: https://www.econbiz.de/10010998476

Testing the equality of diagnostic effectiveness of one measure with respect to k different features

Martinez-Camblor, Pablo; Yanez, Aina - In: Journal of Applied Statistics 36 (2009) 4, pp. 359-367

In several cases the same measurement is used as a marker for two or more population features, and it is useful to test whether this measurement has the same diagnostic effectiveness with respect to different features. In this paper we use the area under receiver operating characteristic curve...

Persistent link: https://www.econbiz.de/10004992272